Products Description of N-Acetylsulfanilyl Chloride CAS#121-60-8
N-Acetylsulfanilyl Chloride is a functional organic compound with the molecular formula C₈H₈ClNO₃S. This chemical exhibits slight acetic acid odor and features strong hygroscopicity, which makes it prone to gradual decomposition when exposed to ambient air. In terms of solubility, it is freely soluble in ethanol and ether, soluble in hot benzene and hot chloroform, and undergoes decomposition in aqueous environments. Strictly sealed and dry storage is required to maintain its structural stability. It serves as a critical organic intermediate widely applicable in pharmaceutical sulfonamide synthesis and industrial dye production.
N-Acetylsulfanilyl Chloride Chemical Properties
| Melting point | 142-145 °C (dec.)(lit.) |
| Boiling point | 426.8±28.0 °C(Predicted) |
| density | 1.2977 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.6300 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| pka | 13.75±0.70(Predicted) |
| form | Granular Crystalline Powder or Crystals |
| color | White to cream-beige |
| Water Solubility | SLIGHTLY SOLUBLE |
| Sensitive | Moisture Sensitive |
| Merck | 14103 |
| BRN | 746676 |
| LogP | 2.05 at 25℃ |
| CAS DataBase Reference | 121-60-8(CAS DataBase Reference) |
| NIST Chemistry Reference | P-acetamidobenzene sulfonyl chloride(121-60-8) |
| EPA Substance Registry System | Benzenesulfonyl chloride, 4-(acetylamino)- (121-60-8) |
| Hazard Codes | C |
| Risk Statements | 22-34-37 |
| Safety Statements | 26-36/37/39-45-28B |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | DB8837500 |
| F | 46286 |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29242995 |
| Hazardous Substances Data | 121-60-8(Hazardous Substances Data) |
| Toxicity | LD50 oral in rat: > 3200mg/kg |
Product Application of N-Acetylsulfanilyl Chloride CAS#121-60-8
N-Acetylsulfanilyl Chloride is a high-value fine chemical intermediate with extensive applications in the pharmaceutical and dye industries. It acts as a core synthetic raw material for manufacturing a full range of sulfonamide antibacterial drugs, including sulfathiazole, sulfisoxazole, sulfamethoxazole, sulfaphenazole and sulfadimethoxazole.
Beyond pharmaceutical synthesis, this versatile intermediate also plays an essential role in the production and processing of industrial dyes, supporting the preparation of multiple dye products in fine chemical manufacturing.
