Products Description of 2-Thiophenecarboxylic Acid CAS#527-72-0
2-Thiophenecarboxylic acid, also named 2-thenoic acid, is a heterocyclic aromatic carboxylic acid with molecular formula C5H4O2S. It appears as white to off-white crystalline powder at ambient temperature, melting at 125-127°C. This product dissolves in hot water and ethanol, with moderate chemical reactivity from thiophene ring and carboxyl functional group.
It is a valuable fine chemical intermediate mainly used for pharmaceutical and agrochemical synthesis. Store it in sealed containers under cool, dry and dark conditions, separated from strong oxidants and alkaline substances.
2-Thiophenecarboxylic Acid Chemical Properties
| Melting point | 125-127 °C(lit.) |
| Boiling point | 260 °C(lit.) |
| density | 1.42 |
| refractive index | 1.5160 (estimate) |
| Fp | 259-261°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Acetone (Slightly), Chloroform (Slightly) |
| form | solid |
| pka | 3.49(at 25℃) |
| color | White to Off-White |
| Water Solubility | 80 g/L (20 ºC) |
| Merck | 149354 |
| BRN | 110150 |
| InChIKey | QERYCTSHXKAMIS-UHFFFAOYSA-N |
| LogP | 1.57 |
| CAS DataBase Reference | 527-72-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Thiophenecarboxylic acid(527-72-0) |
| EPA Substance Registry System | 2-Thiophenecarboxylic acid (527-72-0) |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| RTECS | XM8330200 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29349990 |
Product Application of 2-Thiophenecarboxylic Acid CAS#527-72-0
As a functional carboxylic-acid derivative built upon the thiophene heterocyclic skeleton, 2-Thiophenecarboxylic acid occupies a vital place within fine-chemical manufacturing workflows. Its reactive carboxyl group allows multiple chemical modifications to construct heterocyclic molecular frameworks.
Apart from acting as a fundamental precursor for developing anti-inflammatory and pain-alleviating pharmaceutical products, this compound works as a handy laboratory reagent. Researchers employ it to carry out diverse organic modification experiments and create new-style thiophene-based bio-active intermediates for agrochemical and material-related research.
