Products Description of Diazolidinyl UreaCAS#78491-02-8
Diazolidinyl Urea (CAS No. 78491-02-8) is a synthetic compound with excellent water solubility, presented as an odourless white powder. It is extensively adopted as a broad-spectrum antimicrobial preservative in cosmetic and personal care formulations. As a formaldehyde donor, it suppresses microbial proliferation, with the typical recommended dosage ranging from 0.03% to 0.3%.
Diazolidinyl Urea Chemical Properties
Boiling point | 421.04°C (rough estimate) |
density | 1.4734 (rough estimate) |
vapor pressure | 0Pa at 20℃ |
refractive index | 1.6590 (estimate) |
storage temp. | 2-8°C |
solubility | Water (Slightly) |
form | Solid |
pka | 11.22±0.46(Predicted) |
color | White to Off-White |
Water Solubility | 1000g/L at 20℃ |
Merck | 143000 |
Stability: | Stable. Incompatible with strong oxidizing agents. |
InChIKey | SOROIESOUPGGFO-UHFFFAOYSA-N |
LogP | 0.9 at 20℃ |
CAS DataBase Reference | 78491-02-8(CAS DataBase Reference) |
EPA Substance Registry System | Diazolidinylurea (78491-02-8) |
Hazard Codes | Xi |
Risk Statements | 43 |
Safety Statements | 36/37 |
WGK Germany | 2 |
RTECS | YS2717000 |
HS Code | 29339900 |
Toxicity | LD50 orally in rats: 2.57 g/kg; dermally in rabbits: >2.0 g/kg (Berke, Rosen) |
Product Application of Diazolidinyl Urea CAS# 78491-02-8
Diazolidinyl urea is applicable to both leave-on and rinse-off cosmetic products, such as creams, lotions, shampoos, hair conditioners, liquid cosmetic preparations and eye makeup. It complies with the regulatory requirements for cosmetic use in the United States and the European Union. The recommended dosage normally ranges from 0.1% to 0.3%, and incorporation at temperatures below 50°C is advised. Blending it with parabens and IPBC can further enhance its comprehensive antimicrobial efficacy.
