Products Description of 5-Cyanoindole CAS#15861-24-2
5-Cyanoindole, alternatively named indole-5-carboxynitrile, is an organic compound with a molecular formula of C9H6N2 and a molecular weight of 142.16. This chemical substance is registered under CAS number 15861-24-2 and EINECS number 239-986-4.
Presenting as white to cream crystalline solid, it features a density of 1.2±0.1 g/cm³. Its key physical parameters include a melting point of 106-108°C, a boiling point of 350.0±15.0°C under 760 mmHg atmospheric pressure, and a flash point ranging from 116.3°C to 127.5°C.
Maintaining stable chemical properties under conventional room temperature and normal pressure environments, the product is insoluble in water and exhibits good solubility in methanol solvents.
5-Cyanoindole Chemical Properties
| Melting point | 106-108 °C(lit.) |
| Boiling point | 249.72°C (rough estimate) |
| density | 1.1777 (rough estimate) |
| refractive index | 1.6211 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, Hexane, Methanol |
| form | Crystalline Powder |
| pka | 15.62±0.30(Predicted) |
| color | White to slightly yellow |
| Water Solubility | Soluble in chloroform, hexane and methanol. Insoluble in water. |
| Sensitive | Air & Light Sensitive |
| BRN | 116738 |
| InChIKey | YHYLDEVWYOFIJK-UHFFFAOYSA-N |
| CAS DataBase Reference | 15861-24-2(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-20/21/22 |
| Safety Statements | 26-36-22 |
| RIDADR | 3276 |
| WGK Germany | 3 |
| RTECS | NL5993120 |
| F | 46244 |
| Hazard Note | Irritant |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29339990 |
Product Application of 5-Cyanoindole CAS#15861-24-2
5-Cyanoindole serves as a versatile building block primarily in the pharmaceutical and fine chemical sectors. The cyano group at the 5-position offers a convenient handle for further transformation, enabling the introduction of carboxyl, amine, tetrazole and other functional groups into the indole scaffold. It is extensively employed in the synthesis of serotonin receptor ligands and other central nervous system drug candidates, as well as in the development of kinase inhibitors and heterocyclic pharmaceutical intermediates with potential antitumor, antiviral and anti-inflammatory activities.
Beyond drug discovery, 5-cyanoindole is used in agrochemical research and in the preparation of functional materials such as fluorescent probes and optoelectronic compounds. Its well defined reactivity and broad compatibility with standard coupling and cyclization methods make it a reliable intermediate for medicinal chemists and process development teams, supporting both laboratory scale research and industrial scale synthesis.
